oref/aaos clinical gaps research

We're excited to announce that the second grant to be funded by donations to the Clinical Research Gaps Fund has been selected.

2022 - PI: Kyle Duchman, MD
            Co-PI: Joseph A. Buckwalter IV, MD
            University of Iowa
            Platelet Rich Plasma for Osteoarthritis: Role of Exosomes in Effectiveness

2021 - Scott Rodeo, MD, Hospital for Special Surgery
            PRP Treatment of the ACL-Injured Knee to Decrease the Risk of PTOA


Providing patients with safe, proven, effective treatment options is the goal of every orthopaedic surgeon, but there are areas of practice where clarity does not exist because clinical data is not available. A lack of clear, unbiased data can make it challenging to convince a patient that a particular therapy may be the best option or to educate patients about therapies for which efficacy has not been established.

Through a partnership between the AAOS and OREF, you can help close those data gaps. Please join us in the effort to help support these investigational grants.

Donate to Clinical Gaps Research

• OREF will administer these grants through its peer-review grant process. Applications for the second grant funded through this program will be available in November 2021 and will again address injectable orthobiologics.
• A primary objective of funded studies will be determining clinical efficacy and safety of injectable orthobiologic treatments to provide decreased pain and improved function.
• Studies will also seek to assess the mechanisms of action of injectable orthobiologic treatments in knee osteoarthritis to reduce pain and improve function or modify the progression of disease in patients with knee osteoarthritis.