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OREF/AAOS Clinical Gaps Research Grant


RFA Release Date - 11/9/2023      LOI Deadline - N/A      Application Deadline - 2/8/2024

Grant Details

Solicits investigator-initiated research proposals focused on the broad area of injectable orthobiologics for the treatment of knee osteoarthritis focused on, but not limited to the following areas:

  • Determining clinical efficacy and safety of an injectable orthobiologic treatment(s) to provide decreased pain and improved function, preferably through the assessment of a balanced outcome scorecard measuring patient-reported outcomes and appropriate clinical outcomes.
  • Assessing the mechanisms of action of an injectable orthobiologic treatment(s) in knee osteoarthritis to reduce pain and improve function or modify the progression of disease in patients with knee osteoarthritis.


Applications may be submitted by non-profit, public, and private institutions of higher education such as hospitals, medical schools, universities, and colleges in the United States. OREF requires that an orthopaedic surgeon serve as principal investigator (PI) or Co-PI. The orthopaedic surgeon must be licensed to practice in the U. S. and be working in an institution in the U.S. with active clinical practice. The Principal Investigator is required to be a member of the American Academy of Orthopaedic Surgeons (AAOS). A PhD, DVM or other qualified researcher may serve as a Co-PI, but should hold a faculty appointment in an orthopaedic department at an institution in the U.S

View the RFA on proposalCentral for complete eligibility requirements.

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